MDL72222, a serotonin 5-HT3 receptor antagonist, blocks MDMA's ability to establish a conditioned place preference
by
Bilsky EJ, Reid LD.
Department of Psychology,
Rensselaer Polytechnic Institute,
Troy, NY 12180.
Pharmacol Biochem Behav 1991 Jun;39(2):509-12


ABSTRACT

Methylenedioxymethamphetamine (MDMA) has previously been shown to produce a positive conditioned place preference (CPP) among rats. Here the effects of doses of a specific 5-HT3 antagonist, MDL72222, on MDMA's ability to produce a CPP were assessed. A dose of MDL72222 (0.03 mg/kg) blocked the establishment of a MDMA CPP. These results support the suggestions that compounds affecting the 5-HT3 receptor may be of particular interest in studying the pharmacology of self-administered drugs.

5-HT1b
5-HT1a
5-HT2c
History
MDMA/MDE
Controversies
Protect and survive
Ecstasy and tryptophan
Ecstasy and serotonin synthesis
Ecstasy and the serotonin receptors


Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family