The antinociceptive effects of
(MDMA) in the rat
Crisp T, Stafinsky JL, Boja JW, Schechter MD.
Department of Pharmacology,
Northeastern Ohio Universities,
College of Medicine, Rootstown 44272.
Pharmacol Biochem Behav 1989 Nov;34(3):497-501
ABSTRACTThe antinociceptive effects of MDMA and morphine were examined in rats using the tail-flick and hot-plate analgesiometric tests. MDMA, in the dose range of 1.5-6.0 mg/kg IP, produced a dose-dependent elevation in hot-plate latency, but did not elevate tail-flick latency. In contrast, morphine (2-8 mg/kg, IP) produced analgesia on both the tail-flick and hot-plate tests in a dose-dependent manner. Neither the opiate antagonist naltrexone nor the adrenoceptor antagonist phentolamine effectively attenuated MDMA-induced analgesia. Conversely, the serotonin antagonist methysergide significantly reversed the analgesic effects of MDMA on the hot-plate test. These findings suggest that the antinociceptive effects of MDMA are serotonergically mediated. Furthermore, the results verify earlier findings describing the test-specific effects of serotonin-induced pain modulation.Mice
Protect and survive
Ecstasy and young rats
Ecstasy and serotonin synthesis