Effects of benzylpiperazine derivatives on the neurotoxicity
of 3,4-methylenedioxymethamphetamine in rat brain
by
Hashimoto K, Maeda H, Goromaru T.
Faculty of Pharmacy and Pharmaceutical Sciences,
Fukuyama University, Japan.
Brain Res. 1992 Sep 11;590(1-2):341-4.


ABSTRACT

The neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA) in rat brain was attenuated significantly by coadministration of several benzylpiperazines (p-nitrobenzylpiperazine, p-chlorobenzylpiperazine and 1-piperonylpiperazine), which were weak inhibitors for [3H]6-nitroquipazine binding to the 5-hydroxytryptamine (5-HT) transporter in rat brain. These results suggest that these benzylpiperazines may inhibit the MDMA-induced neurotoxicity by a novel neuropharmacological effect other than 5-HT uptake inhibition.

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