(+/-)3,4-Methylenedioxymethamphetamine ('Ecstasy')-
Induced Serotonin Neurotoxicity: Studies in Animals

by
Ricaurte GA, Yuan J, McCann UD
Department of Neurology,
Johns Hopkins School of Medicine,
Baltimore, Md., USA.
Neuropsychobiology 2000 Jun; 42(1):5-10


ABSTRACT

The popular recreational drug, (+/-)3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a potent and selective brain serotonin (5-HT) neurotoxin in animals. MDMA-induced 5-HT neurotoxicity can be demonstrated using a variety of neurochemical, neuroanatomical and, more recently, functional measures of 5-HT neurons. Although the neurotoxic effects of MDMA in animals are widely accepted, the relevance of the animal data to human MDMA users has been questioned, largely because dosages of drugs used in animals are perceived as being much higher than those used by humans. In the present paper, we review the extensive body of data demonstrating that MDMA produced toxic effects on brain 5-HT neurons in animals and present new data indicating that levels of the type 2 vesicular monoamine transporter are reduced in MDMA-treated animals, providing further indication of MDMA's 5-HT neurotoxic potential. Further, we demonstrate, using principles of interspecies scaling, that dosages of MDMA known to be neurotoxic in animals fall squarely in the range of dosages used typically by recreational MDMA users.
MDMA
Damage
Serotonin
ACEA 1021
Parkinson's?
MDMA/m-CPP
Controversies
MDMA and SSRIs
Ecstasy and Prozac
Human neurotoxicity
L-deprenyl and ecstasy
MDMA: pharmcokinetics
Post-E Prozac protection?
Toxic metabolites of MDMA
Tolerance and cross-tolerance
MDMA, MBDB, fenfluramine, and MMAI


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