Caffeine induces a profound and persistent tachycardia in response to MDMA ("Ecstasy") administration
by
McNamara R, Maginn M, Harkin A.
Department of Pharmacology,
National University of Ireland,
Galway, Ireland.
Eur J Pharmacol. 2006 Nov 3; 2001 Dec;159(1):77-82


ABSTRACT

Caffeine promotes hyperthermia and lethality when co-administered with the recreational drug 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") to rats. In the present study, co-administration of caffeine (10 mg/kg, s.c.) with MDMA (10 mg/kg, s.c.) induced a profound tachycardic response compared to rats treated with either drug alone. However, neither caffeine (30 muM) nor MDMA (1-30 muM), alone or in combination, affected the electrocardiogram of the isolated heart suggesting that central and sympathomimetic actions, rather than direct actions of these drugs on the heart, are responsible for the tachycardia observed in vivo. This is

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