Effects of MDMA exposure on the conditioned place preference
produced by other drugs of abuse

by
Cole JC, Sumnall HR, O'Shea E, Marsden CA.
Department of Psychology,
Eleanor Rathbone Building,
University of Liverpool, L69 7ZAl, Liverpool, UK.
Psychopharmacology (Berl) 2003 Feb 25


ABSTRACT

RATIONALE. MDMA is a serotonergic neurotoxin but few pre-clinical studies have found long-term behavioural consequences. As human users of MDMA are polydrug users, it is important to investigate whether the behavioural effects of other drugs are modulated by prior exposure to MDMA. OBJECTIVES. This study investigated whether pretreatment with a multiple high dose regimen of MDMA altered the rewarding effects of other drugs of abuse. METHODS. Adult male Lister Hooded rats ( n=10/group) were pretreated with 10 mg/kg MDMA or 1 ml/kg saline vehicle IP every 2 h for 6 h. Fourteen days later, conditioned place preference (CPP) to d-amphetamine (3 mg/kg), cocaine (20 mg/kg), ethanol (2.0 g/kg), heroin (0.5 mg/kg), or MDMA (10 mg/kg) was assessed. RESULTS. In general, MDMA pretreatment had no effect on drug reward or habituation to the place conditioning apparatus. However, in contrast to saline pretreated rats, those animals receiving MDMA failed to show CPP after ethanol. CONCLUSION. MDMA pretreatment reduced the rewarding properties of ethanol. This finding may represent a functional consequence of MDMA-induced neurotoxicity. By extrapolation, human users of MDMA may be exposed to an increase in risks associated with alcohol abuse.

Ethanol/MDMA
Oxidative stress
Locomotor effects
MDMA v fenfluramine
Baboons like Ecstasy
Cocaine sensitisation
Anti-Parkinsonian effect
Cutaneous vasoconstriction
MDMA and the mitochondria
Ecstasy/MDMA and cannabis
Arginine-vasopressin release
Phosphatidylinositol turnover
MDMA, loud noise and the heart
MDMA, antihistamines and serotonin
MDMA, HIV and antiretroviral agents
Serotonin, noradrenline and dopamine
MDMA/polydrug users in the UK and Italy


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