Links Strenuous exercise aggravates MDMA-induced
skeletal muscle damage in mice

Duarte JA, Leao A, Magalhaes J, Ascensao A, Bastos ML,
Amado FL, Vilarinho L, Quelhas D, Appell HJ, Carvalho F.
CIAFEL, Faculty of Sport Sciences,
University of Porto,
Rua Dr. Placido Costa 91,
4200 Porto, Portugal.
Toxicology. 2005 Jan 31;206(3):349-58


The aim of this study was to investigate the influence of ecstasy (MDMA) administration on body temperature and soleus muscle histology in exercised and non-exercised mice. Charles-River mice were distributed into four groups: Control (C), exercise (EX), MDMA treated (M), and M + EX. The treated animals received an i.p. injection (10mg/kg) of MDMA (saline for C and EX), and the exercise consisted of a 90min level run at a velocity of 900m/h, immediately after the MDMA or saline administration. Body temperature was recorded every 30min via subcutaneous implanted transponder. Animals were sacrificed 1.5, 25.5, and 49.5h after i.p. injection and the soleus muscles were removed and processed for light and electron microscopy. The MDMA-treated animals showed a significant increase in body temperature (similar in M and M + EX groups), reaching the peak 90min after i.p. administration; their temperature remained higher than control for more than 5h. The EX group evidenced a similar and parallel, yet lower temperature increase during exercise and recovery. Morphological signs of damage were rarely encountered in the EX group; they were more pronounced in M group and even aggravated in M + EX group. In conclusion, MDMA and exercise per se increased body temperature but in conjunction did not have a cumulated effect. However, ecstasy and concomitant physical activity might severely accumulate with regard to skeletal muscle toxicity and may lead to rhabdomyolysis.

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